BRCA1 anticorps (pSer1280)

N° du produit ABIN7452574

Cet anticorps Lapin Polyclonal détecte spécifiquement BRCA1 dans WB et IP. Il présente une réactivité envers Humain.

Aperçu rapide pour BRCA1 anticorps (pSer1280) (ABIN7452574)

Antigène: BRCA1 (Breast Cancer 1 (BRCA1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRCA1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-BRCA1 anticorps

Épitope: pSer1280

Fonction: Rabbit anti-Phospho BRCA1 (S1280) Antibody, Affinity Purified

Homologie: Monkey,Chimpanzee

Purification: Affinity Purified

Immunogène: surrounding serine 1280

Isotype: IgG

Information d'application

Indications d'application:

IP: 2.5 μg/mg lysate

WB: 1:1,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur BRCA1

Antigène: BRCA1 (Breast Cancer 1 (BRCA1))

Autre désignation: BRCA1

Sujet: Background: BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination.

ID gène: 672

NCBI Accession: NP_009225

UniProt: P38398

Pathways: Cycle Cellulaire, Réparation de l'ADN, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus